Life & Medical Sciences Institute (LIMES)
Welcome to the Department of Molecular Developmental Biology!
Head of the Department:
Prof. Michael Hoch, PhD
LIMES-Institute
Director Dept. Molecular Developmental Biology
Carl-Troll-Str. 31
53115 Bonn, Germany
Secretary: Heidrun Schneider-Klinkosch
Phone: +49 (0)2 28 / 73 6 27 37
Fax:+49 (0)2 28 / 73 6 26 39, hoch.sekretariat@uni-bonn.de
Research focus:
We are interested in the molecular mechanisms of cell-to-cell communication and on the regulation of cellular growth and metabolism during tissue and organ formation in Drosophila. In particular, our projects focus on Insulin signalling and the crossregulation of cell growth, ageing and innate immunity, on lipid metabolism and body fat regulation, on new transmembrane proteins and their role in cell specification and tissue formation, on direct cell communcation mediated by the innexin family of gap junction channel proteins, and recent studies have raised our interest in endocytosis-dependent airway physiology. Using genetic screens in the fruit fly Drosophila, we have identified in the last years new key regulators some of which have single orthologs in mice and humans and we have started to analyse their role in mouse models and human tissue culture systems. For our studies, we use in addition to molecular, biochemical and cell biological analysis (including confocal and electron microscopy) a broad range of genetic techniques in Drosophila and mouse.
Research Groups:
NEW:
September 2010:
Harvard Crimson: "Sophomore Studies Genetics and Fruit Flies in Bonn, Germany"
January 21, 2010:
Paper in NATURE on the FoxO-dependent crossregulation of metabolism and innate immunity
Presseartikel der Uni Bonn
Spiegel online: "Hunger weckt Abwehrkräfte"
November 03, 2009:
Paper in EMBO Journal on Schlank that controls growth and body fat
Presseartikel der Uni Bonn
